Triptolide Attenuates Transplant Vasculopathy Through Multiple Pathways
نویسندگان
چکیده
منابع مشابه
Allograft Vasculopathy Versus Atherosclerosis Antibody and Complement in Transplant Vasculopathy Cytokines, Interferon- , and Transplant Vasculopathy Chemokines and Transplant Vasculopathy Stem Cells and Transplant Vasculopathy
Advances in immunosuppression have decreased the incidence of acute rejection, but the development of vasculopathy in the coronary arteries of transplants continues to limit the survival of cardiac allografts. Transplant vasculopathy has also been referred to as accelerated graft arteriosclerosis because it has features of arteriosclerosis, but it is limited to the graft and develops over a per...
متن کاملAllograft Vasculopathy Versus Atherosclerosis Stem Cells and Transplant Vasculopathy Vascular Remodeling and Transplant Vasculopathy Cytokines, Interferon- , and Transplant Vasculopathy Chemokines and Transplant Vasculopathy Antibody and Complement and Transplant Vasculopathy
Over the last 4 decades, heart transplantation (HTx) has evolved as a mainstream therapy for heart failure. Approximately half of patients needing HTx have organ failure consequent to atherosclerosis. Despite advances in immunosuppressive drugs, long-term success of HTx is limited by the development of a particular type of coronary atherosclerosis, referred to as cardiac allograft vasculopathy ...
متن کاملChemokines and transplant vasculopathy.
Transplant vasculopathy (TV) remains the leading cause of late death among heart transplant recipients. Transplant vasculopathy is characterized by progressive neointimal proliferation, leading to ischemic failure of the allograft. Multiple experimental and clinical studies have shown that injury to the graft at various stages of transplantation can be a risk factor for development of transplan...
متن کاملAntibody and Complement in Transplant Vasculopathy Allograft Vasculopathy Versus Atherosclerosis Vascular Remodeling in Transplant Vasculopathy Chemokines and Transplant Vasculopathy Stem Cells and Transplant Vasculopathy William Baldwin and Jordan Pober, Guest Editors Interferon- Axis in Graft Arteriosclerosis
Cardiac transplantation is the most effective treatment for advanced heart failure. Despite improvements in immunosuppression therapy that prevent acute rejection, cardiac allografts fail at rates of 3% to 5% per posttransplant year. The hallmark morphological lesion of chronically failing cardiac allografts, also seen in chronic renal and liver graft failure, is luminal stenosis of blood vesse...
متن کاملFK409, a spontaneous nitric oxide releaser, attenuates allograft vasculopathy in a rat aortic transplant model.
Although systemic administration of NO donors has been shown to attenuate the development of neointimal hyperplasia in the balloon injury model, this strategy has not been tested in a model of allograft vasculopathy. In this study, we investigated the effect of FK409, a spontaneous NO releaser, on the development of allograft vasculopathy, using a rat aortic transplant model. Thoracic aortas fr...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2020
ISSN: 1664-3224
DOI: 10.3389/fimmu.2020.00612